Four simple, sensitive, rapid, accurate and precise simultaneous UV-spectrophotometric methods have been developed and validated for the estimation of Cilnidipine and Telmisartan in combined tablet dosage form. The first method is based on simultaneous equation, 240 (λ max of Cilnidipine) and 296 (λ max of Telmisartan) were selected for the determination of Cilnidipine and Telmisartan respectively in methanol. The principle for second method, AUC curve method is “the area under two points on the mixture spectra is directly proportional to the concentration of the component of interest”. The area selected were 230 to 254 nm and 275.2 to 313 nm for determination of Cilnidipine and Telmisartan respectively. Third method is Dual wavelength in which Cilnidipine was determined by plotting the difference in absorbance at 244 and 291.4 nm (difference is zero for Telmisartan) against the concentration of Cilnidipine. Similarly for the determination of Telmisartan, the difference in absorbance at 284.2 and 346 nm (difference is zero for Cilnidipine) was plotted against the concentration of Telmisartan. The fourth method is based on first order derivative spectroscopy, wavelengths 272.4 nm (ZCP of Telmisartan) and 240.6 nm (ZCP of Cilnidipine) were selected for the estimation of the Cilnidipine and Telmisartan, respectively. All the methods were obeyed Beer’s law. The results of analysis have been validated statistically and by recovery studies. Statistical comparisons prove that there is no significant difference between all this methods. The proposed methods can be successfully applied in routine work for the determination of Cilnidipine and Telmisartan in combined dosage form.
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